2001•Yiyao daobaoRequires access

Comparison of Cisplatin and Carboplatin Cytotoxicity in Gastric Cancer Cell Lines Using the MTT Assay

Bu Shu

Abstract

Objective:To compare the cytotoxicity of cisplatin and carboplatin against gastric cancer cell lines in vitro and provide reference for chemotherapy in clinical practice. Methods:The MTT assay was used to show the percentage inhibition of cell growth and the 50% inhibitory concentration (IC 50 ) at various exposure periods and concentrations. Results:The percentage of inhibition of cell growth by cisplatin was higher than that by carboplatin, and the IC 50 value of cisplatin was far less. Conclusion:Cisplatin was more cytotoxic than carboplatin against gastric call lines in vitro.

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Key concepts: Carboplatin, Cisplatin, MTT assay, Cytotoxicity, Pharmacology, Cancer, In vitro, Cytotoxic T cell