2012•Journal of Beijing University of Traditional Chinese MedicineRequires access
Influences of emodin on expressions of PPAR-αmRNA and PPAR-γmRNA in adipose tissue in KKAy mice with diabetes
Xuezheng Liu
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Abstract
Objective To discuss the effect of emodin for improving insulin sensitivity in lipid tissue and its mechanism of reducing plasma glucose in KKAy mice with diabetes.Methods SPF KKAy mice(n=20) were divided into model group and emodin group[50 mg/(kg·d) intragastrically giving] according to the value of blood glucose,and other 10 C57BL/6J mice were assigned as control group.After 8 weeks the levels of fasting blood glucose(FBG) and fasting insulin(FINS) were detected,the insulin sensitivity index(ISI) was calculated,and triglyceride(TG),total cholesterol(TC),and the expressions of peroxisome proliferator activated receptor-α(PPAR-αmRNA) and peroxisome prliferator activated receptor-γ(PPAR-γmRNA) were determined.Results Compared with normal group,in model group the levels of FBG,TG and TC increased significantly,ISI decreased significantly and the expressions of PPAR-αmRNA and PPAR-γmRNA decreased significantly(P0.05).Compared with model group,in emodin group the levels of FBG,TG and TC decreased significantly,ISI increased significantly and the expressions of PPAR-αmRNA and PPAR-γmRNA increased significantly(P0.05).Conclusion Emodin can up-regulate the expressions of PPAR-αmRNA and PPAR-γmRNA in lipid tissue,reduce plasma glucose and blood fat,and improve insulin sensitivity in KKAy mice with diabetes.