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1980•Acta Chimica SinicaRequires access

REACTIONS OF DIAZONIUM SALTS AND OXIME II. SYNTHESIS OF ARYLALDEHYDES, KETONES AND NITRILES

J Wang

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Abstract

Reactions of aryl diazonium salts with formaldoxime and acetaldoxime at room temperature gave p-acetylbenzaldehyde (1a) (Yield 25%), p-acetaminobenzaldehyde (1b) (Yield 50%), p-Bromoacetophenone (1c) (Yield 60%), p-nitroacetophenone (1d) (Yield 64%), o-chlorobenzonitrile (2a) (Yield 50～57%) and 2, 4-dinitrobenzonitrile (2b) (Yield 54～64%).Reaction of p-acetaminobenzaldehyde (1b) with aminothiourea gave (TB I) (4). Yield 90%, m. p. 223～224℃.

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What this paper is about

Reactions of aryl diazonium salts with formaldoxime and acetaldoxime at room temperature gave p-acetylbenzaldehyde (1a) (Yield 25%), p-acetaminobenzaldehyde (1b) (Yield 50%), p-Bromoacetophenone (1c) (Yield 60%), p-nitroacetophenone (1d) (Yield 64%), o-chlorobenzonitrile (2a) (Yield 50～57%) and 2, 4-dinitrobenzonitrile (2b) (Yield 54～64%).Reaction of p-acetaminobenzaldehyde (1b) with aminothiourea gave (TB I) (4). Yield 90%, m. p. 223～224℃.

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Available abstract

Reactions of aryl diazonium salts with formaldoxime and acetaldoxime at room temperature gave p-acetylbenzaldehyde (1a) (Yield 25%), p-acetaminobenzaldehyde (1b) (Yield 50%), p-Bromoacetophenone (1c) (Yield 60%), p-nitroacetophenone (1d) (Yield 64%), o-chlorobenzonitrile (2a) (Yield 50～57%) and 2, 4-dinitrobenzonitrile (2b) (Yield 54～64%).Reaction of p-acetaminobenzaldehyde (1b) with aminothiourea gave (TB I) (4). Yield 90%, m. p. 223～224℃.

Key concepts: Chemistry, Yield (engineering), Oxime, Aryl, Medicinal chemistry, Organic chemistry, Diazonium Compounds, Alkyl

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REACTIONS OF DIAZONIUM SALTS AND OXIME II. SYNTHESIS OF ARYLALDEHYDES, KETONES AND NITRILES — Research Paper | ScholarLens