2007•Letters in BiotechnologyRequires access

Connective Tissue Growth Factor,a New Target for Anti-Liver Fibrosis

Xue–Fan Bai

Abstract

Connective tissue growth factor(CTGF) and transform growth factor-β(TGF-β) are highly expressed in many fibrotic tissues and organs.It is thought that they are main cytokines promoting fibrogenesis.As the downstream effect media of TGF-β,CTGF mediates its role of promoting fibrosis,but it is not correlated with its role of anti-inflammation and regulation of immunity.For this reason CTGF maybe become a better target for anti-liver fibrosis.

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Available abstract

Key concepts: CTGF, Connective tissue, Fibrosis, Growth factor, Transforming growth factor, Inflammation, Liver fibrosis, Cancer research