ScholarLens Back to search
2006•Unpublished venueRequires access

Effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice

Zeng-Hua Lv

Open publisher page 0 citations

Abstract

Objective To investigate the effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice(OJ).Methods Forty immature male Wistar rats were randomly divided into normal control group,sham operation group,OJ group,OJ+astragalus group.In OJ+astragalus group,astragalus(250 mg/100 g body weight) were given for 7 days.The content of TGF-β1 in serum and liver tissue in rats was detected by ELISA.Results The level of serum TGF-β1 was higher in OJ group and OJ+astragalus group than that in normal control group and sham group.The level of TGF-β1 of liver tissue in OJ+astragalus was lower in than that in OJ group.The morphologic changes of the liver ameliorates in OJ+astragalus group.Conclusion The astragalus helps to improve the liver morphology,decreases the process of liver fibrosis in immature rats with obstructive jaundice.

About this research paper

What this paper is about

Objective To investigate the effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice(OJ).Methods Forty immature male Wistar rats were randomly divided into normal control group,sham operation group,OJ group,OJ+astragalus group.In OJ+astragalus group,astragalus(250 mg/100 g body weight) were given for 7 days.The content of TGF-β1 in serum and liver tissue in rats was detected by ELISA.Results The level of serum TGF-β1 was higher in OJ group and OJ+astragalus group than that in normal control group and sham group.The level of TGF-β1 of liver tissue in OJ+astragalus was lower in than that in OJ group.The morphologic changes of the liver ameliorates in OJ+astragalus group.Conclusion The astragalus helps to improve the liver morphology,decreases the process of liver fibrosis in immature rats with obstructive jaundice.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice(OJ).Methods Forty immature male Wistar rats were randomly divided into normal control group,sham operation group,OJ group,OJ+astragalus group.In OJ+astragalus group,astragalus(250 mg/100 g body weight) were given for 7 days.The content of TGF-β1 in serum and liver tissue in rats was detected by ELISA.Results The level of serum TGF-β1 was higher in OJ group and OJ+astragalus group than that in normal control group and sham group.The level of TGF-β1 of liver tissue in OJ+astragalus was lower in than that in OJ group.The morphologic changes of the liver ameliorates in OJ+astragalus group.Conclusion The astragalus helps to improve the liver morphology,decreases the process of liver fibrosis in immature rats with obstructive jaundice.

Key concepts: Astragalus, Obstructive jaundice, Medicine, Liver tissue, Internal medicine, Fibrosis, Liver injury, Liver fibrosis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of astragalus on serum and liver tissue TGF-β1 level in immature rats with obstructive jaundice — Research Paper | ScholarLens