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2012•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Effects of ginsenoside Rb_2 on chromosome aberration in Chinese hamster lung cells

QU Bao-en

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Abstract

OBJECTIVE:To explore the effects of ginsenoside Rb_2,on chromosome aberration in Chinese hamster lung(CHL) cells.METHODS:We used the method of cell counting to determine the IC_(50) of ginsenoside Rb_2,on CHL cells,then established the range of doses according to the IC_(50) and performed chromosome aberration.The results were based on the chromosome number and structural changes.RESULTS:Negative response was found at 6 h and 24 h after treatment with ginsenoside Rb_2,and at 6 h after the addition of S_9 mixture.CONCLUSION:The ginsenoside Rb_2,did not induce chromosome aberration in CHL cells under our experimental conditions.

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What this paper is about

OBJECTIVE:To explore the effects of ginsenoside Rb_2,on chromosome aberration in Chinese hamster lung(CHL) cells.METHODS:We used the method of cell counting to determine the IC_(50) of ginsenoside Rb_2,on CHL cells,then established the range of doses according to the IC_(50) and performed chromosome aberration.The results were based on the chromosome number and structural changes.RESULTS:Negative response was found at 6 h and 24 h after treatment with ginsenoside Rb_2,and at 6 h after the addition of S_9 mixture.CONCLUSION:The ginsenoside Rb_2,did not induce chromosome aberration in CHL cells under our experimental conditions.

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Available abstract

OBJECTIVE:To explore the effects of ginsenoside Rb_2,on chromosome aberration in Chinese hamster lung(CHL) cells.METHODS:We used the method of cell counting to determine the IC_(50) of ginsenoside Rb_2,on CHL cells,then established the range of doses according to the IC_(50) and performed chromosome aberration.The results were based on the chromosome number and structural changes.RESULTS:Negative response was found at 6 h and 24 h after treatment with ginsenoside Rb_2,and at 6 h after the addition of S_9 mixture.CONCLUSION:The ginsenoside Rb_2,did not induce chromosome aberration in CHL cells under our experimental conditions.

Key concepts: Chinese hamster, Ginsenoside, Chromosome aberration, Chromosome, Chemistry, Molecular biology, Chromosome number, Biology

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Effects of ginsenoside Rb_2 on chromosome aberration in Chinese hamster lung cells — Research Paper | ScholarLens