Progress in the experimental animal bone fracture model research

Experimental animal bone fracture models have been extensively applied as platforms for preclinical research to explain and illustrate the physiological and pathological characters of the bone fracture and to explore new specific maneuvers which can alter the biology and biomechanics of bone.The experimental animal models selected for research should be employed for artificial intervention.The experimental animal models used should be clearly characterized,control group established,and the experiments could be reproduced.By these,the results produced can be compared reliably with other similar studies quantitatively and qualitatively.The aim of this review is to describe the characteristics of the experimental animal bone fracture models applied in diverse fracture healing research and to provide selection guidance of experimental animal models.