2004•Pediatric Emergency MedicineRequires access

Expression of Caspase-1 mRNA in the newborn rats with hypoxic-ischemic brain damage

Chang Li

Abstract

Objective To explore the expression of Caspase-1mRNA in newborn rats with hypoxic-ischemic brain damage (HIBD). Methods A model of HIBD in left brain of seven-day-old Wistar rats was made and the expression of Caspase-1mRNA was measured in cortex at different time points by the reverse-transcription PCR. Microscopical changes were observed.Results Expression of Caspase-1 mRNA in neonatal rats with HIBD increased and reached the highest at HIBD q6h, having a significant difference compared with other groups (P0.05 ).Conclusion HIBD leads to expression of Caspase-1mRNA and Caspase-1 might contribute to occurrence of HIBD in neonates.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Brain damage, Medicine, Messenger RNA, Caspase 3, Pathology, Apoptosis, Molecular biology, Andrology