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2011•Zhongguo quanke yixueRequires access

Research Progress of mTOR Inhibitors in the Treatment of Renal Cell Carcinoma

Liu Wen-h

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Abstract

Mammalian target of rapamycin(mTOR) is a serine / threonine protein kinase,and it plays an important role in the occurrence and development of renal cell carcinoma(RCC).mTOR inhibitors can inhibit cancer gene transformation caused by abnormal mTOR signaling pathway,tumor growth and tumor angiogenesis.Temsirolimus and everolimus are approved in clinical application,and bring new hope for the prognosis of advanced renal cell carcinoma.

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What this paper is about

Mammalian target of rapamycin(mTOR) is a serine / threonine protein kinase,and it plays an important role in the occurrence and development of renal cell carcinoma(RCC).mTOR inhibitors can inhibit cancer gene transformation caused by abnormal mTOR signaling pathway,tumor growth and tumor angiogenesis.Temsirolimus and everolimus are approved in clinical application,and bring new hope for the prognosis of advanced renal cell carcinoma.

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Available abstract

Mammalian target of rapamycin(mTOR) is a serine / threonine protein kinase,and it plays an important role in the occurrence and development of renal cell carcinoma(RCC).mTOR inhibitors can inhibit cancer gene transformation caused by abnormal mTOR signaling pathway,tumor growth and tumor angiogenesis.Temsirolimus and everolimus are approved in clinical application,and bring new hope for the prognosis of advanced renal cell carcinoma.

Key concepts: Temsirolimus, Everolimus, Medicine, PI3K/AKT/mTOR pathway, Renal cell carcinoma, Sirolimus, Cancer research, Discovery and development of mTOR inhibitors

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