2010Chinese Journal of StrokeRequires access

Clinical Analysis of Applying Edaravone Early in Acute Cerebral Infarction

Song Lai

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Abstract

ObJective To observe the effects of edaravone on acute cerebral infarction(ACI). Methods Eighty-two acute cerebral infarction patients who were admitted to hospital 6-72h after onset were randomly divided into treatment group and control group by half.The treatment group was given intravenous edaravone by drops(30 mg edaravone were added to 100 ml physiological saline),twice a day for 14 days.The control group was given the same treatments except edaravone.Conditions of both groups before and after the treatment were evaluated by clinical neurological deficit scores and were compared with each other. Results Fourteen days after treatment,clinical neurological deficit scores of the treatment group were significant lower than that of the control group(P=0.027),14d after treatment,both obvious effects and effects rates of the treatment group were significant higher than that of the control group P=0.016). Conclusion Edaravone is effective on ACI without any serious adverse reaction being observed.

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ObJective To observe the effects of edaravone on acute cerebral infarction(ACI). Methods Eighty-two acute cerebral infarction patients who were admitted to hospital 6-72h after onset were randomly divided into treatment group and control group by half.The treatment group was given intravenous edaravone by drops(30 mg edaravone were added to 100 ml physiological saline),twice a day for 14 days.The control group was given the same treatments except edaravone.Conditions of both groups before and after the treatment were evaluated by clinical neurological deficit scores and were compared with each other. Results Fourteen days after treatment,clinical neurological deficit scores of the treatment group were significant lower than that of the control group(P=0.027),14d after treatment,both obvious effects and effects rates of the treatment group were significant higher than that of the control group P=0.016). Conclusion Edaravone is effective on ACI without any serious adverse reaction being observed.

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Available abstract

ObJective To observe the effects of edaravone on acute cerebral infarction(ACI). Methods Eighty-two acute cerebral infarction patients who were admitted to hospital 6-72h after onset were randomly divided into treatment group and control group by half.The treatment group was given intravenous edaravone by drops(30 mg edaravone were added to 100 ml physiological saline),twice a day for 14 days.The control group was given the same treatments except edaravone.Conditions of both groups before and after the treatment were evaluated by clinical neurological deficit scores and were compared with each other. Results Fourteen days after treatment,clinical neurological deficit scores of the treatment group were significant lower than that of the control group(P=0.027),14d after treatment,both obvious effects and effects rates of the treatment group were significant higher than that of the control group P=0.016). Conclusion Edaravone is effective on ACI without any serious adverse reaction being observed.

Key concepts: Edaravone, Medicine, Anesthesia, Clinical efficacy, Neurological deficit, Saline, Cerebral infarction, Adverse effect

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