The study on evaluation of prognosis of Early Goal Directed Therapy in patients with septic shock

Objective:To investigate the intervene agent and evaluate the effect of Early Goal Directed Therapy on prognosis in patients with septic shock.Methods:60 patients enrolled in this group allocated to two groups,the sufficiently resuscitated group(36 cases) and insufficiently resuscitated group (24 cases)by 6 hours after fluid resuscitation. Correlated haemodynamic parameter before resuscitation,ages,APACHE Ⅱ scores,serum lactic acid concentration,Sequential Organ Failure Assessment (SOFA) score,the volume of the early 6 hours,28 day mortality between the two groups were compared. Results: The ages,blood pressure and APACHE Ⅱ scores between two groups have statistic difference at baseline. There was no significant difference in 6 hours resuscitation volume ,HR,CVP,lactic acid concentration and SOFA scores between the two groups. The 28 days mortalities of two groups were 38.89% and 83.33% respectively.Conclusion: Ages,APACHE Ⅱ scores and blood pressure at baseline can intervene putting the EGDT of practice and EGDT can improve the prognosis of patients with septic shock significantly.