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Effect of adefovir dipivoxil on HBV DNA and HBsAg in serum of patients with chronic hepatitis B

Zhou Yan-fen

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Abstract

Objective To investigate the effect of adefovir dipivoxil on HBV DNA and HBsAg in serum of patients with chronic hepatitis B.Methods The 47 patients with chronic hepatitis B were treated with adefovir dipivoxil for 48 weeks.The levels of HBV DNA were detected by metheod of fluorescence quantitative polymerase chain reaction at 12th,24th,48th week of treatment.The levels of HBsAg were detected by ELISA.Results The levels of HBV DNA and HBsAg in serum of patients with chronic hepatitis B were decreased significantly after treatment with adefovir dipivoxil for 12 weeks(P0.05).The levels of HBV DNA and HBsAg were continued to drop rate along with the progress of treatment.The levels of HBV DNA were 46.07% and 54.21% 24th week and 48th week of treatment,that of HBsAg were 47.55% and 52.45% at 24th week and 48th week of treatment.Conclusion Adefovir dipivoxil can effectively inhibit HBV replication and improve liver function of chronic hepatitis B patients.

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Objective To investigate the effect of adefovir dipivoxil on HBV DNA and HBsAg in serum of patients with chronic hepatitis B.Methods The 47 patients with chronic hepatitis B were treated with adefovir dipivoxil for 48 weeks.The levels of HBV DNA were detected by metheod of fluorescence quantitative polymerase chain reaction at 12th,24th,48th week of treatment.The levels of HBsAg were detected by ELISA.Results The levels of HBV DNA and HBsAg in serum of patients with chronic hepatitis B were decreased significantly after treatment with adefovir dipivoxil for 12 weeks(P0.05).The levels of HBV DNA and HBsAg were continued to drop rate along with the progress of treatment.The levels of HBV DNA were 46.07% and 54.21% 24th week and 48th week of treatment,that of HBsAg were 47.55% and 52.45% at 24th week and 48th week of treatment.Conclusion Adefovir dipivoxil can effectively inhibit HBV replication and improve liver function of chronic hepatitis B patients.

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Available abstract

Objective To investigate the effect of adefovir dipivoxil on HBV DNA and HBsAg in serum of patients with chronic hepatitis B.Methods The 47 patients with chronic hepatitis B were treated with adefovir dipivoxil for 48 weeks.The levels of HBV DNA were detected by metheod of fluorescence quantitative polymerase chain reaction at 12th,24th,48th week of treatment.The levels of HBsAg were detected by ELISA.Results The levels of HBV DNA and HBsAg in serum of patients with chronic hepatitis B were decreased significantly after treatment with adefovir dipivoxil for 12 weeks(P0.05).The levels of HBV DNA and HBsAg were continued to drop rate along with the progress of treatment.The levels of HBV DNA were 46.07% and 54.21% 24th week and 48th week of treatment,that of HBsAg were 47.55% and 52.45% at 24th week and 48th week of treatment.Conclusion Adefovir dipivoxil can effectively inhibit HBV replication and improve liver function of chronic hepatitis B patients.

Key concepts: Adefovir, HBsAg, Chronic hepatitis, Medicine, Hepatitis B, Virology, Gastroenterology, Hepatitis B virus

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