Preliminary discussion on standardization of TCM syndrome distribution law of chronic hepatitis B

Objective:To provide clinical basis for establishing TCM differentiation standardization and preliminaryly summarize the main syndrome standard,minor syndromes standard of TCM syndrome type and syndrome distribution law of chronic hepatitis B.Methods:By a multi-center,large sample of epidemiological research methods,gathering information such as TCM four diagnostic,demography,laboratory index,quality of life scale and something else systematically and standardizedly,and also doing kappa identity test,establishing SPSS database.TCM syndrome type's names and main syndrome,minor syndromes of syndrome type were established by multivariate statistical analysis and the judgment of TCM experts.Results:We altogether obtained five syndromes of chronic hepatitis B,including liver-stagnation and spleen-deficiency syndrome(1 type,19%),spleen-kidney Yang deficiency syndrome(2 type,9%),deficiency of liver and kidney syndrome(3 type,23%),Qi stagnation and blood stasis(4 type,14%),liver-gallbladder dampness heat syndrome(5 type,35%).After studied the correlation between laboratory index and TCM syndromes,we found that ALT,AST had no difference between groups insufficiency and excess syndrome(1 type) and deficiency syndrome(2 and 3 type),groups deficiency syndrome and deficiency syndrome(P0.05);Viral loads had no difference between various syndromes(P0.05),the positive rate of HBeAg was highest in 5 type,it suggested that the virus' activities become strengthen in this type.The level of CD+4 was lowest in 1 type,had difference compared with all other types,while the level of CD+8 was highest in 3 type,had difference compared with all other types except 5 type(P0.05).Observe the relationship between quality of life and syndrome,we found that no matter MOS SF-36 or CLDQ,the scores among the five syndromes in various dimensions show that excessive syndromeinsufficiency and excess syndromdeficiency syndrome,it suggested that the patients'healthy will appear a particular trend changes along with the exchange of asthenia and sthenia of syndrome.Conclusion:According to main syndrome and minor syndromes specification standard,patients with chronic hepatitis B can be randomized into five syndromes,and the various syndromes are correlated with laboratory parameters and quality of live.