Clinical Observation of Plasma Exchange for Treating Patients with Acute Liver Dysfunction

Objective To explore the clinical implications of plasma exchange (PE) in treating patients with multiple organ dysfunction syndrome (MODS).Methods Twenty patients were evenly and randomly divided into MODS with liver dysfunction group (group 1) and acute liver dysfunction induced by non-virus hepatitis group (group 2). Besides integrative medicine treatment,all patients were treated with PE. Total bilirubin,direct bilirubin and alanine aminotransferase (ALT) were determined before and after PE.Results Bilirubin,direct bilirubin and ALT contents were decreased from (240.00±75.53) μmol/L,(139.70±54.35) μmol/L and (111.10±29.76) U/L to (125.00±42.47) μmol/L,(75.30±22.18) μmol/L and (72.90±17.80) U/L after PE in group 1 respectively (P0.01). The case-fatality rate was 80% in group 1. Bilirubin,direct bilirubin and ALT contents were decreased from (207.90±72.68) μmol/L,(102.30±55.37) μmol/L and (120.20±62.54) U/L to (87.60±45.26) μmol/L,(45.20±25.85) μmol/L and (120.20±62.54) U/L after PE in group 2 respectively (P0.01). Death occurred in 0% of group 2. The changes of bilirubin,direct bilirubin and ALT levels and the mortality were significantly different between two groups (P0.01).Conclusion PE is effective to treat acute liver dysfunction,can improve live function and prolong the survival time,but can not ameliorate the prognosis.