Effects of 5% imiquimod cream once a day in 68 patients with condyloma acuminatum

AIM To study the effects of 5% imiquimod cream once a day on condyloma acuminatum.METHODS A total of 98 patients with condyloma acuminatum were assigned to trial group(n = 68)and control group(n = 30),and were respectively administered with 5% imiquimod cream once a day for 4 wk and 5% imiquimod cream once two days for 8 wk.Anatomic site of the wart,wart number,wart morphology,wart size and adverse reactions were observed.RESULTS The effective rates of the trial group and the control group were 69%(46/67)and 73%(22/30)at the end of the treatment,respectively.There was no significant difference in clinical effect between two groups(P 0.05).Wart regression time of the trial group was(12.5 ± 6.5)d,shorter than that of the control group((40.5 ± 12.2)d,P 0.05).There was no significant difference in the incidence of local adverse reactions(50% in the trial group and 40% in the control group,P 0.05).No serious adverse reactions occurred.CONCLUSION In the treatment of condyloma acuminatum,5%imiquimod cream once a day is effective as 5% imiquimod cream once two days,and can shorten the course of treatment.