Therapeutic effect of low dose of intravenous immune globulin combined with metliylprednisolone in the treatment of refractory immunologic thrombocytopenic purpura

Objective To explore the clinical therapentic effect of low dose of intravenous immune globulin (LDIVIG) combined with methylprednisolone in the treatment of refractory immunologic thrombocytopenic purpura (RITP). Methods Twenty inpatients with RITP,who did not respand to hormone therapy and splenectomy, were trented with intravenous drip of LDIVIG 0. 1 g · kg~(-1) ? d~(-1) and oral administration of methylprednisolone tablets for 5 days , the blood pletelet count were recorded and the clinical manifestation of mucosal and visceal hemorrhage were observed before and affer treatment. Results The symptoms of hemorrhage disappeared 72 hours afler treatment, of them marked effect were found in 6 patients,good effect in 4 patients,improvement effect in 2 patients,no effect in 8 patients. The total effective rate was 60%. Conclusion The therapentic effect of LDIVIG combined with methylprednisolone in the treatment of RITP is significant. This therpy can quickly reduce symptom of hemorrhage, and is an effective way to treat RITP.