Pharmacokinetics of compound ofloxacin injection in pig body

To determine the pharmacokinetic parameters of compound ofloxacin injection,also to assess the effects of adjunctive agent-sodium houttufonate to the pharmacokinetic parameters of the principal agent-ofloxacin in compound ofloxacin injection,two group of pigs were injected intramuscularly by the ofloxacin injection(5 mg/kg) and compound ofloxacin injection(5 mg/kg) respectively,followed by blood drug level analyzing in different time points by HPLC,and the pharmacokinetic parameters were calculated by using MCPKP software package.The results showed that there were no significant difference on the blood drug level and pharmacokinetic parameters between the two experimental groups.The maximum blood drug concentration and keep time were almost same with peak time of 0.75 h,the Cmax values of(4.863±0.305) mg·L-1 and(5.128±0.306) mg·L-1,the t1/2β values of(17.974±14.644) h and(23.789±29.902) h,the AUC values of(33.639±2.171) mg·L·h-1 and(36.867±4.253) mg·L·h-1,the Vd values of 1.364 L·kg-1 and 1.316 L·kg-1,respectively.It means that the sodium houttufonate has no effect on the pharmacokinetic parameters of ofloxacin in pig body.