The short-term prognosis of patients with decompensated liver cirrhosis by serum vascular endothelial growth factor and model for end-stage liver disease

Objective To evaluate the short-term prognosis of patients with decompensated liver cirrhosis(DLC)by serum vascular endothelial growth factor (VEGF) and model for end-stage liver disease (MELD). Methods Serum VEGF levels and MELD scores were assessed in 84 patients with DLC. Results The serum VEGF levels and MELD scores were both higher in patients died than in the survivals (P0.005). There was a positive correlation between serum VEGF and MELD or PT(r=0.444,r=0.443,P0.0001). The area under ROC curve was 0.882 in MELD score,while 0.825 in serum VEGF (P0.05). Taking VEGF160.9pg/ml and MELD22.9 as a cut-off value,the specificity was 98.3% and the accuracy was 88.1%. Conclusion Serum VEGF level and MELD score have some clinical prognostic value in patients with DLC.