Effects of Mixed Pesticide on the Functions of Learning and Memory, and the Activities of Na~+-K~+-ATPase and Ca~(2+)-Mg~(2+)-ATPase of Brains in Mice

[Objective] To explore the effects of mixed pesticide on the ability of learning and memory, and the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase of mouse brain. [Methods] Mice were randomly divided into exposure and control groups. The exposure groups A and B were intoxicated with pesticides of profenofos mixed with fenvalerate, and profenofos mixed with methomyl respectively. Each exposure group were further divided into high, medium, and low dose subgroups respectively. The ability of learning and memory in each group was tested by diving tower trial before and after 24 h of exposure, and the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase of the brain were measured in each group after 24 h of intoxication. [Results] Compared with the control group, the error times, the total electric shock period of diving tower trial increased significantly and the latent period of first error shortened significantly in high-dose exposure subgroups of both mixed exposure groups after 24 h of poisoning(P 0.05, P 0.01). The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase also decreased significantly in high-dose exposure subgroups of mixed exposure groups after 24h of poisoning(P 0.05, P 0.01). [Conclusion] The mixed pesticides can harm the ability of learning and memory of mice, which might be related to the decrease of the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in the brain.