Protective effect of aminoguanidine on dopaminergic neurons of the substantia nigra in mice with Parkinson's disease

Objective:To observe the effect of aminoguanidine (AG), the specific inhibitor of induced nitricoxide synthase (iNOS ),on the DA neurons of the Parkinson's disease model mice. Mothods:To make the model mice of PD by lau method. To observe the behavior of the PD mice by the behavioral science and the expression of the iNOS and TH in the gastro-midbrain by western blot, further observe the changes when AG was added. Results:Compared with the control group, the typical performance appeared in the PD model mice, the content of TH in the gastro-midbrain decreased about seventy-seven percent, at the same time, the content of iNOS increased dramatically. Compared with the control group, the behavior of PD mice treated with AG alleviate extremely ,the content of TH decreased about forty-four percent, the content of iNOS was also much lower than that of the control group. Conclusion:The loss of DA neurons in the substantia nigra has correlation with the expression of iNOS, maybe AG can protect the DA neurons.