Evaluation of the coronary in-stent restenosis and neointimal hyperplasia between two kinds of drug eluting stent implantation under intravenous ultrasound

Objective To compare two kinds of drug eluting stent implantation for in-stent restenosis through surveying coronary arterial neointima hyperplasia thickness after 6 month by intravenous ultrasound. Methods Fifty seven volunteers taking part in IVUS form serious 242 DES patiens(Drug Eluting Stent)with implantation 6 months during January 2005 to December 2006 vs. 49 volunteers from 251 BMS(Bare Metal Stent)patients as the contrast were surveyed and compared for neointima hyperplasia thickness. Results Neointima hyperplasic area: Cypher group 1.11 ± 0.89 mm2,vs. Firebird group 1.13 ± 0.08 mm2,and stent restenosis rate: Cypher group(9.0 ± 0.1)%,vs. Firebird group(10.0 ± 0.2)%; revealed no significant difference between the two groups. DES groups with BMS showed the neointima hyperplasic area as 1.44 ± 0.04 mm2,stent restenosis rate as(21.0 ± 0.1)%,P 0.05,the difference is significant. Stent segment stenosis in the distal parts showed no difference between DES and BMS groups. The proximal parts of stent stenosis showed as BMS group(0.29 ± 0.13)% vs. Cypher group(0.43 ± 0.25)% Firebird group(0.40 ± 0.15)% outcoming with P 0.05; the differences were significant. Conclusion DES stent is superior to BMS stent in preventing in-stent restenosis and BMS is probably superior to DES in preventing stent segment restenosis. IVUS survey is more preeise than coronary angiography.(J Intervent Radiol,2007,16: 657-660)