Determination of in Vitro Adhesion and Dissolution Rate of Total Puerariae Flavones(TPF)Bioadhesive Sustained-release Tablets

OBJECTIVE:To study the dissolution rate of total puerariae flavones(TPF)bioadhesive sustained-release tablet,and to determine its bioadhesive force to animal stomach and small intestine in vitro METHODS:Using rotating basket method,the dissolubility summation was determined with 0 1mol/L HCl as dissolution medium at speed of 100r/min,single-index model,Weibull distributing model,Higuchi equation and zero-class model were used to imitate the dissolution curve The biggest absolute error,the biggest relative error and AIC were used as comprehensive indices to select the best imitating model A new apparatus made by ourselves was used to compare the adhesive force between the sustained-release tablets and popular tablets in adhering to rabbits'stomach or small intestine RESULTS:The results showed that the dissolution rate in vitro imitated in single-index model was the best Bioadhesion study showed that there were obvious differences between bioadhesive sustained-release tablets and non-bioadhesive tablets in adhering with gastric mucosa and small intestines mucosa(P0 01),and the bioadhesion to small intestines mucosa was stronger than to gastric mucosa(P0 05) CONCLUSIONS:The dissolution rate in vitro of the sustained-release tablets conforms to single-index model The adhesive force of TPF bioadhesive sustained-release tablets is stronger than that of non-bioadhesive tablets