Study on the Prognosis in Patients with Septic Shock by Dynamic Monitoring the Lactate Level of Arterial Blood

Objective To evaluate the correlation between the lactate in artery blood,lactate clearance rate and prognosis in patients with septic shock.Methods Thirty patients with septic shock from January 2008 to June 2010 were treated by early goal-directed therapy(EGDT).They were divided into survival group and dead group by prognosis.Blood concentration of lactate after admission to ICU and 6-hours lactate were detected,and 6-hour lactate clearance rate were calculated.They were divided into low lactate clearance rate group and high lactate clearance rate group depending on whether the rate below 10% or above 10%.Compare the 28-day mortality rate between the two groups.Results Significant differences of the lactate level after admission,6 hours and the lactate clearance rate of 6 hours were found between death group and survival group(P0.01).The mortality rate of patients with high lactate clearance rate within 6 hours and low lactate clearance rate within 6 hours showed significant difference(P0.01).Conclusion Patients with high arterial blood concentration of lactate and low 6-hour lactate clearance rate have an unfavorable prognosis.The 6-hour lactate clearance rate can be used as a good marker to predict prognosis of septic shock patients.