Comparative Observation of the Inhibiting Effects Between Midazolam and Dexmedetomidine on Postoperative Agitation with Sevoflurane Anesthesia

Objective To observe the roles of midazolam and dexmedetomidine in postoperative agitation after sevoflurane anesthesia. Methods 180 patients aged from 25~60, underwent general anesthesia in Department of General Surgery of hour hospital were selected and randomly divided into group A, group B and group C with 60 cases in each according to digital table method.All patients were induced and maintained by sevoflurane-remifentanyl general anesthesia. 15 minutes before the end of the operation, the patients in group A were intravenous administration dexmedetomidine 1μg/kg(5min), while group B with midazolam0.05mg/kg, group C intravenous injection of 0.9% saline 10ml. The BP and HR were recorded at the time point of as soon as administration of drugs, 5 and 10 minutes after administration. The time of operation, anesthesia, postanaesthetic recovery and staying in the recovery room was also been recorded. Scores on postoperative emergence agitation were accessed to calculate the effect of drugs. Results The time of postanaesthetic recovery and incidence of postoperative agitation in group A and group B were lower than those in group C(P0.05), and those in group A were lower than those in group B(P0.05). There were no significantly differences between the three groups of patients in the indexes of respiration and circulation during the operation(P0.05), the differences in operation time, anesthesia time and time of staying in the recovery room between the three groups were not statistically significant(P0.05). Conclusion The effect of clinical dose of dexmedetomidine on sevoflurane-remifentanil general anesthesia emergence agitation is better than that of midazolam.