The changes of periodontal clinical parameters and osteocalcin level in GCF during the initial stage of the integrated orthodontic and periodontal treatment of moderate to severe periodontal patients

Objective To monitor the periodontal status during the initial stage of orthodontic therapy in moderate to severe periodontal patients by detection of periodontal clinical parameters in the initial stage of orthodontic therapy and osteocalcin level in GCF after the first stress application.Methods 15 patients,with moderate to severe periodontitis,were selected as the experimental group.The PLI,BI and PD were examined by electrochemical luminescence at pre-treatment,1st month and 2nd month after the treatment respectively,while the OC level in GCF were examined before orthodontic treatment,1,24,48,and 168 hours after the first stress application.The indices of the control group,formed by 15 orthodontic patients who had healthy periodontal status,were compared.Results After the periodontal treatment,the periodontal clinical levels of the experimental group were lower than pre-treatment levels(P0.05),while those after orthodontic treatment were not significantly different from before(P0.05).The level of OC in the experimental group after the first stress application was significantly higher than that after the orthodontic treatment(P0.05),and peaked at 24th hour,but went down to pre-treatment level at 168th hour,which was the same as that of the control group.Conclusion Integrated orthodontic and periodontal treatment can improve the periodontal status in moderate to severe periodontal patients.Osteocalcin should be involved in bone remodeling in earlier orthodontic treatment.