Research on Myocardium Protection Mechanism of Ginkgo Biloba Extracts in Type 2 Diabetes Rats

【Objective】To study effect of Ginkgo biloba extracts on lipid metabolism and the peroxisome proliferators activated receptorγmRNA(PPARγmRNA) expression of the myocardium cell in the experimental type 2 diabetes rats and therapeutic effect of Ginkgo biloba extracts on the type 2 diabetes.【Method】Diabetes rat models were induced by high glucose and high fat feedstuff and low-dosage streptozotocin.The rats were randomized into model group(10) and therapy group(10) whose fasting blood-glucose(FBG) is more than16.6 mmol/L.Normal control group(10) is set.The rats of therapy group were lavaged with Ginkgo biloba extracts,the other groups were lavaged with 0.9% NaCl.After 10 weeks,we detected blood lipoid,FBG,blood insulin(INS) for calculating insulin resistance index(IRI),the content of MDA and SOD.The content of PPARγmRNA expression all groups was detected by RT-PCR.【Result】The content of PPARγmRNA expression in therapy group was higher,MDA was decreased,SOD was increased,FBG,FINS and IRI were decreased compared with the model group.【Conclusion】Ginkgo biloba extracts could decrease the blood sugar and insulin resistance,improve lipid peroxidation,increase the content of PPARγmRNA expression of myocardium in type 2 diabetes rats.Ginkgo biloba extracts has therapeutic effect on type 2 diabetes.