The changes of interleukin-1βin cerebral cortex and hippocampus in rats with complete brain ischemia reperfusiion injury

Objective To explore changes of interleuin-1β(IL-1β)in cerebral cortex and hippocampus.Method The complete cerebral ischemia and ischemia reperfusion model was made,changes of IL-1βimmunoreactive positive cells in cerebral cortex and hippocampus during pre ischemia,ischemia and ischemia reperfusion periods were observed and analysed using immunohistochemical method.Result There is no difference between pre ischemia and ischemia periods.An hour after reperfusion,the number of il-1βimmunoreactive positive cells in hippocampus is much more and much deeper than the ones of the previous two periods.Two hours after reperfusion,the number of IL-1βimmunoreactive positive cells in parietal lobe cortex is much more and much deeper than the ones of the previous two periods.Conclusion There is close relation between interleukin-1βand complete brain ischemia reperfusion injury.Hippocampus is more sensitive than cerebral cortex to complete brain ischemia reperfusion.