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2000•PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSRequires access

Progress in Vascular Endothelial Growth Factor.

Jiao Bing

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Abstract

Vascular endothelial growth factor(VEGF) induces angiogenesis as well as permeability of blood vessels,and plays a central role in the regulation of vasculogenesis.Five VEGF isoforms (VEGF 121～206 ) are produced from a single VEGF gene by alternative splicing of the VEGF mRNA.The regulation of angiogenesis induced by VEGF and how to inhibit its effects arouse great interests.The function of VEGF in angiogenesis regulation was reviewed in several aspects.

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What this paper is about

Vascular endothelial growth factor(VEGF) induces angiogenesis as well as permeability of blood vessels,and plays a central role in the regulation of vasculogenesis.Five VEGF isoforms (VEGF 121～206 ) are produced from a single VEGF gene by alternative splicing of the VEGF mRNA.The regulation of angiogenesis induced by VEGF and how to inhibit its effects arouse great interests.The function of VEGF in angiogenesis regulation was reviewed in several aspects.

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Available abstract

Vascular endothelial growth factor(VEGF) induces angiogenesis as well as permeability of blood vessels,and plays a central role in the regulation of vasculogenesis.Five VEGF isoforms (VEGF 121～206 ) are produced from a single VEGF gene by alternative splicing of the VEGF mRNA.The regulation of angiogenesis induced by VEGF and how to inhibit its effects arouse great interests.The function of VEGF in angiogenesis regulation was reviewed in several aspects.

Key concepts: Angiogenesis, Vasculogenesis, Vascular endothelial growth factor, Vascular endothelial growth factor B, VEGF receptors, Vascular endothelial growth factor C, Gene isoform, Cell biology

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