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Study on Contents of GABA、Glu、Tau and Gly of Hippocampus in Rats With Seizure

Zhilin Zhang

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Abstract

Objective: To investigate the changes and action of amino acids in epilepsy rat models. Methods A status epilepticus model was established by intra-peritoneal injection of Pentylenetetrazole(PTZ) in rats . The extracellular amino acid neurotransmission was measured in vivo by microdialysis with HPLC before and after PTZ administration. Results The extracellular GABA concetration in the CAI area decreased immediately after the administration of PTZ but increased at about 3 d after PTZ injection and lasted about 2 weeds. However,Glu level increased remarkably after the PTZ injection and decreased 3 d after PTZ injection and lasted until the 14th day. Conclusions The results suggests that a imbalance between excitatory and inhibitory neuronal systems play a critical role in the mechanism of seizure.

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What this paper is about

Objective: To investigate the changes and action of amino acids in epilepsy rat models. Methods A status epilepticus model was established by intra-peritoneal injection of Pentylenetetrazole(PTZ) in rats . The extracellular amino acid neurotransmission was measured in vivo by microdialysis with HPLC before and after PTZ administration. Results The extracellular GABA concetration in the CAI area decreased immediately after the administration of PTZ but increased at about 3 d after PTZ injection and lasted about 2 weeds. However,Glu level increased remarkably after the PTZ injection and decreased 3 d after PTZ injection and lasted until the 14th day. Conclusions The results suggests that a imbalance between excitatory and inhibitory neuronal systems play a critical role in the mechanism of seizure.

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Available abstract

Objective: To investigate the changes and action of amino acids in epilepsy rat models. Methods A status epilepticus model was established by intra-peritoneal injection of Pentylenetetrazole(PTZ) in rats . The extracellular amino acid neurotransmission was measured in vivo by microdialysis with HPLC before and after PTZ administration. Results The extracellular GABA concetration in the CAI area decreased immediately after the administration of PTZ but increased at about 3 d after PTZ injection and lasted about 2 weeds. However,Glu level increased remarkably after the PTZ injection and decreased 3 d after PTZ injection and lasted until the 14th day. Conclusions The results suggests that a imbalance between excitatory and inhibitory neuronal systems play a critical role in the mechanism of seizure.

Key concepts: Microdialysis, Status epilepticus, Epilepsy, Excitatory postsynaptic potential, Hippocampus, Inhibitory postsynaptic potential, Extracellular, Pharmacology

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