The relaionship between serum ferritin and insulin resistance in patients with nonalcoholic fatty liver disease

Objective:To investigate the relationship of serum ferritin and insulin resistance in patients with non-alcoholic fatty liver disease(NAFLD) alone and NAFLD combined with type 2 diabetes.Methods:A total of 41 with NAFLD alone,76 NAFLD patients with type 2 diabetes and 60 healthy controls were studied.Abdominal ultrasound was taken for fatty liver examination.Serum ferritin and insulin levels were determined by radioimmunoassay(RIA).Insulin resistance indexes were assessed by the homeostasis assessment-insulin resistance(HOMA-IR).Other biochemical variables were measured by routine methods.Results:Compared with healthy controls,the BMI,ALT,AST,TC,LDL,FBG,FINS,HOMA IR,HbA1C,UAlb/UCr and SF significantly increased in NAFLD patient with type 2 diabetes.Compared with NAFLD patients,insulin resistance was more serious in NAFLD with type 2 diabetes.Correlation analysis showed FBG,HOMA IR and HbA1C were closely related with SF.Conclusion:Serum iron metabolism is closely related with insulin resistance.Therefore,reduce of insulin resistance and correction of SF are important to prevent NAFLD.