Comparion of muscle relaxant effects of cisatracuronium on orbicularis oculi and adductor pollicis

Objective To compare the muscle relaxant effects of cisatracuronium on the orbicularis oculi and adductor pollicis.Methods Twenty patients undergoing elective operations under general anesthesia were given 0.10 mg/kg of cisatracuronium (2ED95) intravenously for endotracheal intubation during induction. Two acceleromyography (TOF-Watch sx) were used to determine the neuromuscular blockade of the orbicularis oculi and adductor pollicis simultaneously. Results The onset times for orbicularis oculi and adductor pollicis relaxation were (194±40) s and (187±39) s,the no-response period (14.31±3.78) min and (23.73±7.40) min (P0.01),the recovery time to 25% of T1 (31.08±8.14) min and (36.71±8.47) min (P0.05),and the recovery time to 75% of T1 (46.22±9.07) min and (49.76±11.11) min respectively. Conclusion The adductor pollicis is a better site for monitoring the muscle relaxant effect of cisatracuronium in moderate dose.