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Effects of Sodium TanshinoneIIA Sulfonate on Hyperlipidemic Fatty Liver Lipid Peroxidation Rats

Yifan Zhang

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Abstract

Objective To study the effects of sodium tanshinoneⅡA sulfonate(STS) on hyperlipidemic fatty liver lipid peroxidation rats and its possible mechanism.Methods HFL model rats were induced by high fat diet for 8 weeks,and divided into four groups randomly:HFL model group,STS(H: high dose) group,STS(L:low dose) group and polyene phosphatidylcholine capsules(PPC) group (PPC was closen to be the control medicine).The pathological changes in liver,levels of blood-fat, ALT,AST,SOD,MDA in serum,levels of TC,TG,SOD,MDA in liver were monitored after six weeks. Results STS could decrease the level of TC,TG,MDA in plasma and hepatic index,the level of serum LDL-C content and ALT,AST activities,while increase the level of SOD activity and HDL-C content in serum and liver and also reduce distribution of lipid droplet in extent and scope in liver cells.Conclusion STS could treat the hyperlipidemic fatty liver rats induced by feeding with high fat diet through improving fat metabolism disorder,reducing levels of liver lipid,lipid peroxide products and the fatty deposited in liver,and improving the function of periphery adipose tissue.

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What this paper is about

Objective To study the effects of sodium tanshinoneⅡA sulfonate(STS) on hyperlipidemic fatty liver lipid peroxidation rats and its possible mechanism.Methods HFL model rats were induced by high fat diet for 8 weeks,and divided into four groups randomly:HFL model group,STS(H: high dose) group,STS(L:low dose) group and polyene phosphatidylcholine capsules(PPC) group (PPC was closen to be the control medicine).The pathological changes in liver,levels of blood-fat, ALT,AST,SOD,MDA in serum,levels of TC,TG,SOD,MDA in liver were monitored after six weeks. Results STS could decrease the level of TC,TG,MDA in plasma and hepatic index,the level of serum LDL-C content and ALT,AST activities,while increase the level of SOD activity and HDL-C content in serum and liver and also reduce distribution of lipid droplet in extent and scope in liver cells.Conclusion STS could treat the hyperlipidemic fatty liver rats induced by feeding with high fat diet through improving fat metabolism disorder,reducing levels of liver lipid,lipid peroxide products and the fatty deposited in liver,and improving the function of periphery adipose tissue.

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Available abstract

Objective To study the effects of sodium tanshinoneⅡA sulfonate(STS) on hyperlipidemic fatty liver lipid peroxidation rats and its possible mechanism.Methods HFL model rats were induced by high fat diet for 8 weeks,and divided into four groups randomly:HFL model group,STS(H: high dose) group,STS(L:low dose) group and polyene phosphatidylcholine capsules(PPC) group (PPC was closen to be the control medicine).The pathological changes in liver,levels of blood-fat, ALT,AST,SOD,MDA in serum,levels of TC,TG,SOD,MDA in liver were monitored after six weeks. Results STS could decrease the level of TC,TG,MDA in plasma and hepatic index,the level of serum LDL-C content and ALT,AST activities,while increase the level of SOD activity and HDL-C content in serum and liver and also reduce distribution of lipid droplet in extent and scope in liver cells.Conclusion STS could treat the hyperlipidemic fatty liver rats induced by feeding with high fat diet through improving fat metabolism disorder,reducing levels of liver lipid,lipid peroxide products and the fatty deposited in liver,and improving the function of periphery adipose tissue.

Key concepts: Lipid peroxidation, Internal medicine, Endocrinology, Lipid peroxide, Chemistry, Lipid metabolism, Fatty liver, Liver function

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Effects of Sodium TanshinoneIIA Sulfonate on Hyperlipidemic Fatty Liver Lipid Peroxidation Rats — Research Paper | ScholarLens