Serum uric acid level and its related factors in school-age children with obesity

Objectives To investigate the serum uric acid level and its related factors in obese children. Methods Obese children were selected from all pupils(ages 7-14) of 3 primary schools. Age-and sex-matched children with normal body mass index(BMI) were chosen as normal controls. Fasting venous blood samples were collected to detect uric acid(UA), glucose(GLU), total cholesterol(CHOL), triacylglycerol(TG), high-density lipoprotein cholesterol(HDL-C) and low-density lipopro-tein cholesterol(LDL-C). Results Sixty-eight(2.2%) obese children(57 boys and 11 girls) were detected from 3 000 children. Compared with 136 normal controls, the blood pressure(BP), levels of UA, CHOL, TG and LDL-C, and waist circumference(WC) were higher while HDL-C was lower in obese children(P0.05). The detection rate of hyperuricemia in obese children(35.3%) were significantly higher than that in normal controls(5.9%)(P0.05). UA was positively related with WC, BMI, BP and TG, negatively related with HDL-C. Conclusions Obesity can lead to higher serum UA, higher BP and abnormal lipid metabolism. The level of serum UA was correlated with BP and abnormal lipid metabolism.