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2002•Chinese Journal of Industrial MedicineRequires access

The experimental study on apoptosis of hippocampus and cortex cells in rat offsprings exposed to lead

Lu Xiao

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Abstract

Objective To study the developmental neurotoxicity.Method The offsprings of rats exposed to lead during pregnant and breast feeding period were used to determine the lead content in blood and brain,the apoptotic cells in hippocampus and cortex were also assayed by TUNEL method.Result The number of apoptotic cells in hippocampus and nearby cortex increased in the young rats at the 7th day after birth,but no obvious change in those at the 21st day after birth.Conclusion Lead could induce developmental neurotoxicity by excessive apoptosis of hippocampus and nearby cortex cells during developmental period.

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Objective To study the developmental neurotoxicity.Method The offsprings of rats exposed to lead during pregnant and breast feeding period were used to determine the lead content in blood and brain,the apoptotic cells in hippocampus and cortex were also assayed by TUNEL method.Result The number of apoptotic cells in hippocampus and nearby cortex increased in the young rats at the 7th day after birth,but no obvious change in those at the 21st day after birth.Conclusion Lead could induce developmental neurotoxicity by excessive apoptosis of hippocampus and nearby cortex cells during developmental period.

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Available abstract

Objective To study the developmental neurotoxicity.Method The offsprings of rats exposed to lead during pregnant and breast feeding period were used to determine the lead content in blood and brain,the apoptotic cells in hippocampus and cortex were also assayed by TUNEL method.Result The number of apoptotic cells in hippocampus and nearby cortex increased in the young rats at the 7th day after birth,but no obvious change in those at the 21st day after birth.Conclusion Lead could induce developmental neurotoxicity by excessive apoptosis of hippocampus and nearby cortex cells during developmental period.

Key concepts: Hippocampus, Neurotoxicity, Apoptosis, Cortex (anatomy), TUNEL assay, Biology, Cerebral cortex, Period (music)

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