The Comparison of effectiveness and safety between the different doses of clopidogrel in the patients after percutaneous coronary intervention

Objective To investigate the effectiveness and safety of 50mg/d clopidogrel in the patients after percutaneous coronary intervention(PCI).Methods A total of 119 patients with coronary heart disease(CHD)were randomly divided into two groups including group A(75mg/d)and group B(50mg/d).300 mg of clopidogrel were given to all patients on the day before PCI.75 mg of clopidogrel was given for 1 year on group A,while 150 mg of clopidogrel were given for 30 days and 50 mg of clopidogrel as maintenance-dose for at least 1 year on group B.The end points included major adverse cardiac and cerebral events(including death,stent thrombosis,in-stent restenosis,non-fatal myocardial infarction,target vessel revascularization)and other adverse reactions.Results There was no significant difference in the incidence of major cardiovascular adverse effects and other side effects between two groups(P0.05).Conclusion The maintenance-dose of 50 mg/d clopidogrel can effectively prevent in-stent restenosis without increment of cardiovascular adverse effects.