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2004•Chinese Journal of Disease Control and PreventionRequires access

The oxidant injury induced by phosgene of lung in mice

Wang Pen

Open publisher page 1 citations

Abstract

Objective To study oxidative injury of lung in different time in mice after exposed to phosgene. Methods 40 mice were randomly divided into 4 groups. The mice in control group were exposed to air and the mice in case group were exposed to 11.9 mg·L -1 phosgene for 5 minutes, respectively. After 2 hours, 4 hours, 8 hours, all mice were killed and wet/dry radio, the content of malondialdehyde (MDA), reductive glutathion (GSH) and activities of the total superoxide dismutase (T-SOD) in lung were detected. Results With the time prolonged, wet/dry radio increased significantly ( P0.05). After 4 hour, MDA content and T-SOD activity increased significantly ( P0.05). GSH content decreased significantly in positive group, compared with negative group after 2 hours of phosgene exposure (P0.05). Conclusions Phosgene might induce pulmonary edema and oxidative injury of lung in mice.

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What this paper is about

Objective To study oxidative injury of lung in different time in mice after exposed to phosgene. Methods 40 mice were randomly divided into 4 groups. The mice in control group were exposed to air and the mice in case group were exposed to 11.9 mg·L -1 phosgene for 5 minutes, respectively. After 2 hours, 4 hours, 8 hours, all mice were killed and wet/dry radio, the content of malondialdehyde (MDA), reductive glutathion (GSH) and activities of the total superoxide dismutase (T-SOD) in lung were detected. Results With the time prolonged, wet/dry radio increased significantly ( P0.05). After 4 hour, MDA content and T-SOD activity increased significantly ( P0.05). GSH content decreased significantly in positive group, compared with negative group after 2 hours of phosgene exposure (P0.05). Conclusions Phosgene might induce pulmonary edema and oxidative injury of lung in mice.

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Available abstract

Objective To study oxidative injury of lung in different time in mice after exposed to phosgene. Methods 40 mice were randomly divided into 4 groups. The mice in control group were exposed to air and the mice in case group were exposed to 11.9 mg·L -1 phosgene for 5 minutes, respectively. After 2 hours, 4 hours, 8 hours, all mice were killed and wet/dry radio, the content of malondialdehyde (MDA), reductive glutathion (GSH) and activities of the total superoxide dismutase (T-SOD) in lung were detected. Results With the time prolonged, wet/dry radio increased significantly ( P0.05). After 4 hour, MDA content and T-SOD activity increased significantly ( P0.05). GSH content decreased significantly in positive group, compared with negative group after 2 hours of phosgene exposure (P0.05). Conclusions Phosgene might induce pulmonary edema and oxidative injury of lung in mice.

Key concepts: Phosgene, Malondialdehyde, Superoxide dismutase, Glutathione, Chemistry, Pulmonary edema, Lung, Oxidative stress

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