2009•Tianjin Yike Daxue xuebaoRequires access

Protective effect of propofol postconditioning on brain ischemic injury in rats

Yonghao Yu

Abstract

Objective:To investigate the protective effect of propofol postconditioning on neuronal cells after focal cerebral ischemia in rats.Methods:Middle cerebral artery occlusion models were performed in SD rats.54 rats were randomly divided into 3 groups (n =18 each):S group,sham control;I/R group,ischemia-reperfusion group;P group,ischemia-reperfusion with intraperitoneal propofol postconditioning.The neurological deficit score,cerebral infarct volume,apoptotic index with TUNEL staining,levels of Bcl2 and Bax with Western blotting were detected.Results:Propofol reduced the cerebral infarct volume,inhibited apoptotic index,increased the level of Bcl2 and decreased Bax level.Conclusion:Propofol can inhibit the neuron apoptosis after focal cerebral ischemia and reperfusion injury in rats.

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Key concepts: Propofol, Medicine, TUNEL assay, Ischemia, Anesthesia, Apoptosis, Reperfusion injury, Middle cerebral artery