The preventive and curative effects of Nimodipine to hypoxic-ischemic brain damage in the neonatal rats

Purpose: Hypoxic ischemic brain damage is a kind of severe deseases, it endangers neonates' life and health. The neonatal rats HIBD model was set up to explore the preventive and curative effects of Nimodipine. Meterials and Methods: 32 SD rats with 7 day old were divided into four groups(1)Sham operation, (2)HIBD, (3)HIBD+Nimodipine A groups, (4)HIBD+Nimodipine B groups. Except for the group one, the others were made in HIBD models. In the (3)? (4)groups, Nimodipine were administered intraperitoneally. For all rats, the brain tissue were removed to make the pathologic observation and to measure the content of water? calcirm and excitatory amino acids after 24 hours. Results: 1. The content of water? calcium? Glu? Asp and the number of degenerative and necrotic neurocytes in brain tissue were signiicantly increased( P 0.01), and the number of neurons in the brain decreased in group(2)compared with group(1). 2. The change of pathology were lightened significantly in group(3)and (4)compared with group(2). Co0nclusion: Nimodipine had obvious preventive and curative effects on the experimental HIBD of neonatal rats and provided a credible theoretical basis for prevention and curation of HIBD in the neonate.