Relationships among HBV DNA and HBV immunological markers in patients with chronic hepatitis type B

Objective To investigate the relationship among HBV DNA and HBV immunological markers in patients with chronic hepatitis type B.Methods The amount of HBV DNA in the serum of 200 patients were estimated by FQ-PCR.The serum HBV immunological markers of these patients were tested with ELISA.Results The amount of HBV DNA was different in 3 HBV immunological markers groups.The amount of HBV DNA in HBsAg,HBeAg and(or) HBeAb positive samples was higher than that in other groups with positive rate of 98.1%.The HBV DNA positive raw of HBsAg,HBeAg and(or) HBeAb positive samples was 76.5%;The positive rate of HBcAb positive samples was 65%;The positive rate of HBcAb/HBeAb/HBsAb positive samples was 13%,but all of them,HBV DNA≤103cope/ml.Each group were difference in HBV DNA result.Conclusion FQ-PCR has high sensitivity and specificity.The amount of HBV DNA with HBV immunological markers has important signification in diagnosis and judgement of patients with chronic hepatitis type B.