Clinical significance of detection of serum osteopontin in patient with pancreatic cancer

Objective To evaluate the value of detection of serum osteopontin level in the clinical diagnosis and the prognosis assessment of pancreatic cancer.Methods The serum levels of OPN,CEA,CA19-9 in 30 patients with pancreatic cancer and 20 healthy volunteers were measured by enzyme-linked immunosorbent assay and electrical chemiluminescence immunoassay.Receiver operating characteristics curve (ROC) was used to compare the diagnostic sensitivity and specificity of OPN,CEA,and CA19-9 in the patients with pancreatic cancer.The value of OPN in the diagnosis of pancreatic cancer was assessed.Results The serum levels of OPN,CA19-9 and CEA in the patients with pancreatic cancer[(79.2±42.1)ng/mL,(397.5±360.0)U/mL,(4.3±3.8)μg/mL)] were higher than [(31.2±25.6)ng/mL,(37.0±26.2)U/mL,(2.3±2.7)μg/mL)(P0.01 or P0.05)]in healthy subjects.The area under curve of the serum levels of OPN,CA19-9 and CEA in diagnosis of pancreatic cancer in receiver operator characteristic curve were 0.825±0.059,0.860±0.059,0.749 ±0.075,respectively.Conclusion The serum osteopontin is increased significantly in patients with pancreatic cancer.The serum OPN may be an important maker to assess the outcome of pancreatic cancer monitor the efficacy of clinical treatment,to assess prognosis.Combined detection with serum OPN,CA19-9,CEA can improve the rate of diagnosis.It also has important significance for the screening of pancreatic cancer.