2008•Guiding Journal of Traditional Chinese Medicine and PharmacyRequires access

Effects of PTS on Expression of Nogo-A Following Focal Ischemia-Reperfusion in Rats

Yuqing Hou

Abstract

Objective: To investigate the expression of Nogo-A and the effect of PTS on it following focal ischemia-reperfusion in the rat brain.Methods: The model of 72 cases of acute middle cerebral ischemia-reperfusion injury in rats established.The expression of Nogo-A protein in different durations of reper-fusion(3 d,7 d) was determined by Western blotting and immunohistochemical approach,and the functional scoring was also evaluated.Results: Western blotting showed Nogo-A proein expression was decreased on day 3 and increased significantly on day 7.Immunohistochemical approach showed the same results.The number of Nogo-A-immunoreactive cells at 3 d after reperfusion in PTS group decrease compared with the placebo group(P0.05).And the number at 7 d in PTS group decreased markedly and represent significant difference compared with the placebo group(P0.05).Conclusion: The study implies PTS could down-regulate the expression of Nogo-A,and it might be one of protective mechanisms of PTS against ischemia-reperfusion injury.

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Key concepts: Blot, Immunohistochemistry, Ischemia, Medicine, Reperfusion injury, Placebo, Placebo group, Internal medicine