Association of serum 25 (OH) vitamin D levels with ulcerative colitis activity

Objective To determine serum 25(OH) vitamin D levels in patients with ulcerative colitis(UC) and analyze the association of serum 25(OH) vitamin D concentrations with disease activity. Methods A total of 40 ulcerative colitis patients and 30 healthy controls were enrolled in the study, 25(OH) vitamin D serum concentrations were measured by ELISA kit, clinical disease activity was calculated using the Mayo index, the relationship of vitamin D levels with clinical data and clinical disease activity was analyzed. Results Serum Vitamin D levels were found to be lower in patients with ulcerative colitis(15.8±12.3)ng/ml than in healthy controls(42.5±26.7)ng/ml,( p0.05), but not related significantly to patients age, gender, average duration of UC diagnosis, current medication antibiotics NSAIDs and 5-ASA, however, related significantly to the medication of Steroids and disease activity. Conclusion Vitamin D deficiency in patients with active ulcerative colitis is related to the medication of Steroids and disease activity.