Expression of Fas/FasL in lung cancer and its significance.

Objective To study the expression and significance of Fas/FasL in lung cancers. Methods The expression of Fas/FasL were detected in 60 cases of lung cancer, the same cases of paracancer tissues of lung cancer and 20 cases of normal lung tissues by immunohistochemical method, and its correlations with clinical stages, pathological types, metastatic states of lymph nodes were studied. Results The rate of positive expression of Fas/FasL in the tissues of lung cancer was lower than it in paracancerous tissues and in normal lung tissues, It was significantly difference(P0.05). The rate of positive expression of Fas and FasL is significantly lower in the tissues of NSCLS than those in the tissues of SCLS (P0.05), and there are no significantly difference among the tissues of each types lung caner (P0.05). The rate of positive expression of Fas is no significantly difference with PTNM and metastatic lymponode. The rate of positive expression of FasL is significantly positive relation with PTNM and metastatic lymponode. Conclusion These experimental results were suggested that Fas/FasL play an important roles in oncogenesis and progression of lung cancer.