Differentiation between Infantile Hepatitis Syndrome and Biliary Atresia with Hepatobiliary Scintigraphy and Laboratory Examination Results

Objective To investigate the value of hepatobiliary scintigraphy and laboratory examination results in the different diagnosis between infantile hepatitis syndrome(IHS) and congenital extrahepatic biliary atresia(EHBA).Methods The sera of 36 infants with persistent jaundice were collected and separately detected for AST,ALT,LDH,GGT,ALP,TBILI,DBILI and IBILI by biochemical assay.And the hepatobiliary scintigraphy was performed meanwhile.Results The sensitivity of hepatobiliary scintigraphy in detecting IHS and EHBA in 36 infants was 85%(17/20)and 100%(16/16),specificity was 100%(16/16)and 85%(17/20).The levels of AST,LDH,ALT,GGT,ALP,TBILI,IBILI and DBILI were above the reference range.The levels of TBILI and DBILI were higher in infants with EHBA than in infants with IHS(P0.05),whereas the levels of AST,LDH,ALT,GGT,ALP and IBILI were similar between them(P0.05).Conclusion Hepatic damage is common in infants with IHS and EHBA.Hepatobiliary scintigraphy combined with laboratory examination results is of value to the differential diagnosis between IHS and EHBA.