2008•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access

Expression and significance of FEZ1 mRNA in esophageal squamous cell carcinoma

Li Na

Abstract

Objectives To investigate the expression and significance of tumor suppressor gene FEZ1 mRNA in esophageal squamous cell carcinoma.MethodsThe expression of FEZ1 mRNA in 50 cases of esophageal carcinoma and 50 cases of normal esophageal mucoma were detected by reverse transcription-polymerase chain reaction(RT-PCR).Results The positive expression rate and relative contents of FEZ1 mRNA in esophageal squamous cell carcinoma(48.0%, 0.994±0.094) were significantly lower than in normal esophageal mucoma(84.0%, 1.071± 0.181).The positivity and relative contents of FEZ1 mRNA in esophageal squamous cell carcinoma correlated with lymph node metastasis(P 0.05).ConclusionLoss of FEZ1 gene expression may be related to lymph node metastasis in esophageal squamous cell carcinoma.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Esophageal squamous cell carcinoma, Carcinoma, Messenger RNA, Metastasis, Reverse transcription polymerase chain reaction, Pathology, Lymph node metastasis, Cancer research