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2001•Zhongguo yaolixue yu dulixue zazhiRequires access

Effects of diacetylmonoxime and HI-6 on soman clearance from blood in rats

Ying Xiang

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Abstract

The effects of both carboxylesterase reactivator, diacetylmonoxime(DAM) and cholinesterase reactivator, HI 6 on the disappearance of soman from blood in rats intoxicated with soman(415 μg·kg -1 ,5 LD 50 ,iv) were studied using electric eel acetylcholinesterase based microassay. In rats pretreated with DAM the soman concentration was significantly reduced during 3-10 min, which might be partly due to its reactivation of carboxylesterase in detoxifying organs, and thereby increased efficacy of endogenous detoxifying enzymes. By contrast, HI 6 had negligible effects on soman clearance from blood in rats. It suggests that carboxylesterase is more important than cholinesterase in soman detoxification in rats.

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What this paper is about

The effects of both carboxylesterase reactivator, diacetylmonoxime(DAM) and cholinesterase reactivator, HI 6 on the disappearance of soman from blood in rats intoxicated with soman(415 μg·kg -1 ,5 LD 50 ,iv) were studied using electric eel acetylcholinesterase based microassay. In rats pretreated with DAM the soman concentration was significantly reduced during 3-10 min, which might be partly due to its reactivation of carboxylesterase in detoxifying organs, and thereby increased efficacy of endogenous detoxifying enzymes. By contrast, HI 6 had negligible effects on soman clearance from blood in rats. It suggests that carboxylesterase is more important than cholinesterase in soman detoxification in rats.

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Available abstract

The effects of both carboxylesterase reactivator, diacetylmonoxime(DAM) and cholinesterase reactivator, HI 6 on the disappearance of soman from blood in rats intoxicated with soman(415 μg·kg -1 ,5 LD 50 ,iv) were studied using electric eel acetylcholinesterase based microassay. In rats pretreated with DAM the soman concentration was significantly reduced during 3-10 min, which might be partly due to its reactivation of carboxylesterase in detoxifying organs, and thereby increased efficacy of endogenous detoxifying enzymes. By contrast, HI 6 had negligible effects on soman clearance from blood in rats. It suggests that carboxylesterase is more important than cholinesterase in soman detoxification in rats.

Key concepts: Soman, Carboxylesterase, Cholinesterase, Acetylcholinesterase, Chemistry, Pharmacology, Nerve agent, Butyrylcholinesterase

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Effects of diacetylmonoxime and HI-6 on soman clearance from blood in rats — Research Paper | ScholarLens