1999•Zhonghua shenjing waike zazhiRequires access

The effect of TRH analogue, YM-14673, on spinal cord edema after spinal cord injury in rat

JI Yuanq

Abstract

Objectiver To study the effect of TRH analogue, YM-14673, on spinal cord edema after spinalcord injury in rat. Methods The models of spinal cord injury in rat were built by Allen's method. And the rat weredivided into three group: normal, treated, and contrast. The rat in the treated group were injected with YM-14673.The water content in spinal cord were measured with weighting which formula is: (wet weight-dry weight)÷wetweight×100%. Results The spinal cord edema in treated group decreased significantly after the spinal cord injury.Conclusions The early use of TRH analogae, YM-14673 can decrease the spinal cord edema after spinal cord inju-ry.

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Key concepts: Spinal cord, Edema, Spinal cord injury, Medicine, Anesthesia, Cord, Internal medicine, Surgery