Determination of 169 Pesticide Residues in Grains by Gas Chromatography Tandem Mass Spectrometry

A method was developed for the simultaneous determination of 169 pesticides in grains by gas chromatography with tandem mass spectrometry(GC-MS/MS).The homogenized sample was extracted with acetonitrile,and then purified by QuEChERS,The targeted compounds were detected by GC-MS/MS system under the mode of multiple reaction monitoring(MRM).The results indicated that the limits of detection(LODs) of 169 pesticides were ranged from 0.3 to 13.0 μg/kg.The LOQs of the tested pesticides were between 1.0 and 40.0 μg/kg.In the linear range between 0.005 and 2.0 mg/L of each pesticide,the linear correlation coefficients were greater than 0.99.The average recoveries ranged from 65.3% to 143.6% and the RSDs of 97% pesticides were less than 20%.This method was suitable for the identification and quantification of multi-component pesticides in grains due to its simplicity,good purification and high sensitivity.