Experimental Study on the Effect of Filtration on the Platelet Preparations

Objective The effect of filtration on the platelet preparations was observed,and platelet preparations suited to platelet filtration were selected.Method The filtration effect of apheresis platelet,platelets concentration and their relative frozen platelets was studied while observing the platelet recovery rate,leukocyte removal rate,platelet con-centrationrateandvariousplateletfunctionindexes.Results Theplateletrecoveryrateforapheresisplateletwas 86.81%,while manual concentrated platelet was only 73.08%.The platelet loss rate for two frozen platelet preparations was 60%～70%.After filtration,the apheresis platelet met the leukocyte filtration standard,whereas manually-collected plated did not meet the leukocyte reduction standard.Filtration did not have significant impact on the function of platelet preparations stored in liquid,but the function of manual platelets was significantly lower than that of apheresis platelet.Conclusion Frozen stored platelet preparations are not suitable for leukocyte filtration due to the significant platelet loss.Currently the quality of manually concentrated platelets are inferior to that of apheresis platelet,and there is a need to develop quality leukocyte filters.The apheresis platelet is of good quality and could meet the leukocyte reduction standard using home-made filters,thus making it an ideal platelet preparation for leukocyte filtration.