Non Inradiation as Conditioning Regimen for Allogeneic Peripheral Blood Hematopoietic Stem Cell Transplantation in Twenty Patients Malignant Hematopoietic Diseases

Objective To evaluate the clinical effect of allogeneic peripheral blood stem cell transplantation(allo-PBSCT) by non-intradiation treatment on malignant hematopoietic diseases.Methods 19 patients with acute and chronic leukemia and 1 with SLE combined with Sezary Syndrome underwent allo-PBSCT from HLA-identical siblings.The conditioning regimen consisted of the high dose combination chemotherapy Busulfan(Bu)+ Cytarabine(Ara-c)+ cyclophosphamide(CTX))+ Me-CCNU and a decreased dose combination chemotherapy:Bu + Ara-c+ CTX+Fludarabine(Flu).Cyclosporine-A(CsA) plus a short course of MTX was used for GVHD prophylaxis in the patients.Results After transplantation,median time for the recovery of granuocyte ≥0.5×10~9/ L and platelets ≥20×10~9/ L were 13(11～18) and 14(13～25) days,Of 20 cases, 5 developed chronic GVHD.All of 20 survivals did not show HVOD and insterstitial pneumonia(IP).After follow-up for 19.6(3～66)months,18 patients were still disease-free survival,1 patient who died of gastric cancer in 3 year after transplant.One patient relapsed.Conclusion Non TBI as conditioning regimen is effective for patients with CML and AML,relatively easy to administer,with low extramedullary toxicities.However,it is not effective enough for patients with All.